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Article

Two Rab2 interactors regulate dense-core vesicle maturation.

Neuron - 2 Apr 2014

Ailion Michael, Hannemann Mandy, Dalton Susan, Pappas Andrea, Watanabe Shigeki, Hegermann Jan, Liu Qiang, Han Hsiao-Fen, Gu Mingyu, Goulding Morgan Q, Sasidharan Nikhil, Schuske Kim, Hullett Patrick, Eimer Stefan, Jorgensen Erik M

Abstract excerpt

Peptide neuromodulators are released from a unique organelle: the dense-core vesicle. Dense-core vesicles are generated at the trans-Golgi and then sort cargo during maturation before being secreted. To identify proteins that act in this pathway, we performed a genetic screen in Caenorhabditis elegans for mutants defective in dense-core vesicle function. We identified two conserved Rab2-binding proteins: RUND-1,...

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Identifiers

PMID: 24698274
DOI: 10.1016/j.neuron.2014.02.017
PMCID: PMC3997996

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