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Article

The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.

Molecular biology of the cell - 1 Mar 2011

Noakes Christopher J, Lee Grace, Lowe Martin

Abstract excerpt

Mutation of the inositol polyphosphate 5-phosphatase OCRL1 results in two disorders in humans, namely Lowe syndrome (characterized by ocular, nervous system, and renal defects) and type 2 Dent disease (in which only the renal symptoms are evident). The disease mechanisms of these syndromes are poorly understood. Here we identify two novel OCRL1-binding proteins, termed inositol polyphosphate phosphatase...

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Source

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Identifiers

PMID: 21233288
DOI: 10.1091/mbc.E10-08-0730
PMCID: PMC3046058

Genes

APPL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.PMID 21233288Read ↗

A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.Semantic proximity Read ↗

Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1Semantic proximity Read ↗

The cellular and physiological functions of the Lowe syndrome protein OCRL1.Semantic proximity Read ↗

The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.Semantic proximity Read ↗

All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding.Semantic proximity Read ↗

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism.Semantic proximity Read ↗

Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRLSemantic proximity Read ↗

Differential clathrin binding and subcellular localization of OCRL1 splice isoforms.Semantic proximity Read ↗

Compensatory Role of Inositol 5-Phosphatase INPP5B to OCRL in Primary Cilia Formation in Oculocerebrorenal Syndrome of LoweSemantic proximity Read ↗

The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric TubuleSemantic proximity Read ↗

Structure and function of the Lowe syndrome protein OCRL1.Semantic proximity Read ↗

The oculocerebrorenal syndrome of Lowe: an update.Semantic proximity Read ↗

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