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Article

Differential prevalence of the HLA-C -- 35 CC genotype among viremic long term non-progressor and elite controller HIV+ individuals.

Immunobiology - 1 Sept 2012

Ballana Ester, Ruiz-de Andres Alba, Mothe Beatriz, Ramirez de Arellano Eva, Aguilar Francisco, Badia Roger, Grau Eulalia, Clotet Bonaventura, del Val Margarita, Brander Christian, Esté José A

Abstract excerpt

Susceptibility to HIV infection and disease progression are complex traits modulated by environmental and genetic factors, affecting innate and adaptive immune responses, among other cellular processes. A single nucleotide polymorphism (SNP) 35 kb upstream of the HLA-C gene locus (-35C/T) was previously shown to correlate with increased HLA-C expression and improved control of HIV-1. Here, we genotyped the -35C/T...

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PMID: 22333575
DOI: 10.1016/j.imbio.2011.12.012

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