Protective Effect of HLA-B*5701 and HLA-C -35 Genetic Variants in HIV-Positive Caucasians from Northern Poland.

doi:10.1371/journal.pone.0127867

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Protective Effect of HLA-B*5701 and HLA-C -35 Genetic Variants in HIV-Positive Caucasians from Northern Poland.

PloS one - 1 Jan 2015

Leszczyszyn-Pynka Magdalena, Aksak-Wąs Bogusz, Urbańska Anna, Parczewski Miłosz

Abstract excerpt

AIM OF THE STUDY: Association of two HLA class I variants with HIV-1 pretreatment viremia, CD4+ T cell count at the care-entry and CD4+ T cell nadir. METHODS: 414 HIV-positive Caucasians (30% women) aged 19-73 years were genotyped for HLA-C -35 (rs9264942) and HLA-B*5701 variants. HIV-1 viral load, as well as CD4+ T cell count at care-entry and nadir, were compared across alleles, genotypes and haplotypes....

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PMID: 26068923
DOI: 10.1371/journal.pone.0127867
PMCID: PMC4465896

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