Article
Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection.
AIDS (London, England) - 2 Jan 2009
van Manen Daniëlle, Kootstra Neeltje A, Boeser-Nunnink Brigitte, Handulle Muna Am, van't Wout Angélique B, Schuitemaker Hanneke
Abstract excerpt
BACKGROUND: Recently, a genome-wide association analysis revealed single-nucleotide polymorphisms (SNPs) in the gene regions of HLA-C and HCP5 to be associated with viral load at set point and SNPs in the RNF39/ZNRD1 gene region to be associated with HIV-1 disease course. METHODS: We studied whether the association of these SNPs with viral load at set point could be replicated and whether these SNPs also...
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