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Article

SPK-1, an SR protein kinase, inhibits programmed cell death in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2011

Galvin Brendan D, Denning Daniel P, Horvitz H Robert

Abstract excerpt

To identify genes involved in protecting cells from programmed cell death in Caenorhabditis elegans, we performed a genetic screen to isolate mutations that cause an increase in the number of programmed cell deaths. We screened for suppressors of the cell-death defect caused by a partial loss-of-function mutation in ced-4, which encodes an Apaf-1 homolog that promotes programmed cell death by activating the...

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PMID: 21245325
DOI: 10.1073/pnas.1018805108
PMCID: PMC3033281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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