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Article

SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development.

Mechanisms of development - 1 Dec 2000

Kuroyanagi H, Kimura T, Wada K, Hisamoto N, Matsumoto K, Hagiwara M

Abstract excerpt

SR-protein kinases (SRPKs) and their substrates, serine/arginine-rich pre-mRNA splicing factors, are key components of splicing machinery and are well conserved across phyla. Despite extensive biochemical investigation, the physiological functions of SRPKs remain unclear. In the present study, cDNAs for SPK-1, a C. elegans SRPK homologue, and CeSF2, an SPK-1 substrate, were cloned. SPK-1 binds directly to and...

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PMID: 11091073
DOI: 10.1016/s0925-4773(00)00477-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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