Article
The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.
Oncogene - 28 Apr 2011
Mazot P, Cazes A, Boutterin M C, Figueiredo A, Raynal V, Combaret V, Hallberg B, Palmer R H, Delattre O, Janoueix-Lerosey I, Vigny M
Abstract excerpt
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK), which is transiently expressed during development of the central and peripheral nervous system. ALK has been recently identified as a major neuroblastoma predisposition gene and activating mutations have also been identified in a subset of sporadic neuroblastoma tumors. Two hot spots of ALK mutations have been observed at positions F1174 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.