Article
Molecular Modeling for Structural Insights Concerning the Activation Mechanisms of F1174L and R1275Q Mutations on Anaplastic Lymphoma Kinase.
Molecules (Basel, Switzerland) - 2 Jul 2018
Jiang Cheng-Han, Huang Chong-Xian, Chen Ya-Jyun, Chuang Yu-Chung, Huang Bo-Yen, Yang Chia-Ning
Abstract excerpt
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase involved in various cancers. In its basal state, the structure of ALK is in an autoinhibitory form stabilized by its A-loop, which runs from the N-lobe to the C-lobe of the kinase. Specifically, the A-loop adopts an inhibitory pose with its proximal A-loop helix (αAL-helix) to anchor the αC-helix orientation in an inactive form in the N-lobe; the...
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