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Article

Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.

PloS one - 1 Jan 2012

Mazot Pierre, Cazes Alex, Dingli Florent, Degoutin Joffrey, Irinopoulou Théano, Boutterin Marie-Claude, Lombard Bérangère, Loew Damarys, Hallberg Bengt, Palmer Ruth Helen, Delattre Olivier, Janoueix-Lerosey Isabelle, Vigny Marc

Abstract excerpt

Recently, activating mutations of the full length ALK receptor, with two hot spots at positions F1174 and R1275, have been characterized in sporadic cases of neuroblastoma. Here, we report similar basal patterns of ALK phosphorylation between the neuroblastoma IMR-32 cell line, which expresses only the wild-type receptor (ALK(WT)), and the SH-SY5Y cell line, which exhibits a heterozygous ALK F1174L mutation and...

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Share to Anaplastic Lymphoma Kinase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proteasome Endopeptidase Complex

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Source

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Identifiers

PMID: 22479414
DOI: 10.1371/journal.pone.0033581
PMCID: PMC3316580

Genes

ALK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.PMID 22479414Read ↗

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