Article
Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684.
The Biochemical journal - 15 Dec 2011
Schönherr Christina, Ruuth Kristina, Yamazaki Yasuo, Eriksson Therese, Christensen James, Palmer Ruth H, Hallberg Bengt
Abstract excerpt
Mutations in the kinase domain of ALK (anaplastic lymphoma kinase) have recently been shown to be important for the progression of the childhood tumour neuroblastoma. In the present study we investigate six of the putative reported constitutively active ALK mutations, in positions G1128A, I1171N, F1174L, R1192P, F1245C and R1275Q. Our analyses were performed in cell-culture-based systems with both mouse and human...
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