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Article

Partial deletion of the ALK gene in ALK-positive anaplastic large cell lymphoma.

Hematological oncology - 1 Feb 2018

Fukuhara Suguru, Nomoto Junko, Kim Sung-Won, Taniguchi Hirokazu, Miyagi Maeshima Akiko, Tobinai Kensei, Kobayashi Yukio

Abstract excerpt

Anaplastic lymphoma kinase (ALK) protein is an orphan receptor tyrosine kinase that is constitutively activated by aberrant translocations of the ALK gene in anaplastic large cell lymphoma, ALK-positive and several other cancers. Additionally, aberrant mutation and amplification of the ALK gene, resulting in ALK kinase activation, were detected mainly in neuroblastoma. Recently, truncated ALK protein was also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28665006
DOI: 10.1002/hon.2455

Genes

ALK
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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