KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

doi:10.1158/1078-0432.CCR-10-1720

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Article

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2011

Tie Jeanne, Lipton Lara, Desai Jayesh, Gibbs Peter, Jorissen Robert N, Christie Michael, Drummond Katharine J, Thomson Benjamin N J, Usatoff Valery, Evans Peter M, Pick Adrian W, Knight Simon, Carne Peter W G, Berry Roger, Polglase Adrian, McMurrick Paul, Zhao Qi, Busam Dana, Strausberg Robert L, Domingo Enric, Tomlinson Ian P M, Midgley Rachel, Kerr David, Sieber Oliver M

Abstract excerpt

PURPOSE: Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse. EXPERIMENTAL DESIGN: One hundred colorectal cancer metastases were screened for mutations in 19 oncogenes, and further 61 metastases and 87 matched primary cancers were...

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Identifiers

PMID: 21239505
DOI: 10.1158/1078-0432.CCR-10-1720

Genes

KRAS
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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