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Article

Mutational profiles of primary pulmonary adenocarcinoma and paired brain metastases disclose the importance of KRAS mutations.

European journal of cancer (Oxford, England : 1990) - 1 Dec 2021

Vassella Erik, Kashani Elham, Zens Philipp, Kündig Alexandra, Fung Christian, Scherz Amina, Herrmann Evelyn, Ermis Ekin, Schmid Ralph A, Berezowska Sabina

Abstract excerpt

BACKGROUND: Brain metastases present a significant complication in lung cancer with an unmet therapeutic need. METHODS: In this single-centre, retrospective study, we genotyped a clinico-pathologically well-annotated cohort of consecutively resected brain metastases of lung adenocarcinomas and paired primary tumours, diagnosed from 2000 to 2015, using the Ion Torrent Oncomine Comprehensive Cancer Panel v3....

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Identifiers

PMID: 34781171
DOI: 10.1016/j.ejca.2021.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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