Article
KRAS mutations in primary colorectal cancer tumors and related metastases: a potential role in prediction of lung metastasis.
PloS one - 18 Dec 2009
Cejas Paloma, López-Gómez Miriam, Aguayo Cristina, Madero Rosario, de Castro Carpeño Javier, Belda-Iniesta Cristóbal, Barriuso Jorge, Moreno García Víctor, Larrauri Javier, López Rocío, Casado Enrique, Gonzalez-Barón Manuel, Feliu Jaime
Abstract excerpt
BACKGROUND: KRAS mutations in colorectal cancer primary tumors predict resistance to anti-Epidermal Growth Factor Receptor (EGFR) monoclonal antibody therapy in patients with metastatic colorectal cancer, and thus represent a true indicator of EGFR pathway activation status. METHODOLOGY/PRINCIPAL FINDINGS: KRAS mutations were retrospectively studied using polymerase chain reactions and subsequent sequencing of...
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