Article
EGFR, BRAF and KRAS status in patients undergoing pulmonary metastasectomy from primary colorectal carcinoma: a prospective follow-up study.
Annals of surgical oncology - 1 Mar 2014
Schweiger Thomas, Hegedüs Balazs, Nikolowsky Christoph, Hegedüs Zita, Szirtes Ildiko, Mair Roland, Birner Peter, Döme Balazs, Lang György, Klepetko Walter, Ankersmit Hendrik Jan, Hoetzenecker Konrad
Abstract excerpt
BACKGROUND: Pulmonary metastasectomy is an integral part of the interdisciplinary treatment of patients with pulmonary metastases (PMs) from colorectal carcinoma (CRC). Although alterations in the epidermal growth factor receptor (EGFR) pathway are common in CRC, there is still insufficient data regarding PM. We hypothesized that EGFR expression and Kirsten rat sarcoma viral oncogene homolog (KRAS)/BRAF mutations...
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