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Article

RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer.

Cancer - 15 Apr 2015

Yaeger Rona, Cowell Elizabeth, Chou Joanne F, Gewirtz Alexandra N, Borsu Laetitia, Vakiani Efsevia, Solit David B, Rosen Neal, Capanu Marinela, Ladanyi Marc, Kemeny Nancy

Abstract excerpt

BACKGROUND: RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and brain. METHODS: We performed a computerized search of the electronic medical record of our institution for mCRC cases...

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Identifiers

PMID: 25491172
DOI: 10.1002/cncr.29196
PMCID: PMC4523078

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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