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Article

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

16 Jan 2007

Abstract excerpt

Mitochondrial dysfunction is implicated in the pathophysiology of Parkinson's disease (PD), a common age-associated neurodegenerative disease characterized by intraneuronal inclusions (Lewy bodies) and progressive degeneration of the nigrostriatal dopamine (DA) system. It has recently been demonstrated that midbrain DA neurons of PD patients and elderly humans contain high levels of somatic mtDNA mutations, which...

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PMID: 17227870
DOI: 10.1073/pnas.0605208103

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