Article
BRCA1 allele-specific expression in genetic predisposed breast/ovarian cancer.
Familial cancer - 1 Apr 2017
Jamard Estelle, Volard Bertrand, Dugué Audrey Emmanuelle, Legros Angelina, Leconte Alexandra, Clarisse Bénédicte, Davy Grégoire, Polycarpe Florence, Dugast Catherine, Abadie Caroline, Frebourg Thierry, Tinat Julie, Tennevet Isabelle, Layet Valérie, Joly Florence, Castéra Laurent, Berthet Pascaline, Vaur Dominique, Krieger Sophie
Abstract excerpt
Germline allele specific expression (ASE), resulting in a lowered expression of one of the BRCA1 alleles, has been described as a possible predisposition marker in Hereditary Breast or Ovarian Cancer (HBOC), usable for molecular diagnosis in HBOC. The main objective of this prospective case-control study was to compare the proportion of ASE between controls without familial history of breast or ovarian cancer,...
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