Article
The cost of antibiotic resistance depends on evolutionary history in Escherichia coli.
BMC evolutionary biology - 2 Aug 2013
Angst Daniel C, Hall Alex R
Abstract excerpt
BACKGROUND: The persistence of antibiotic resistance depends on the fitness effects of resistance elements in the absence of antibiotics. Recent work shows that the fitness effect of a given resistance mutation is influenced by other resistance mutations on the same genome. However, resistant bacteria acquire additional beneficial mutations during evolution in the absence of antibiotics that do not alter...
Topics
- Adaptation, Physiological
- Anti-Bacterial Agents
- Biological Evolution
- Drug Resistance, Bacterial
- Escherichia coli
- Genotype
- Mutation
- Plasmids
- Rifampin
- Streptomycin