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Article

The competitive cost of antibiotic resistance in Mycobacterium tuberculosis.

Science (New York, N.Y.) - 30 Jun 2006

Gagneux Sebastien, Long Clara Davis, Small Peter M, Van Tran, Schoolnik Gary K, Bohannan Brendan J M

Abstract excerpt

Mathematical models predict that the future of the multidrug-resistant tuberculosis epidemic will depend on the fitness cost of drug resistance. We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost and that this cost is determined by the specific resistance mutation and strain genetic background. In contrast, we...

Read the complete abstract on PubMed

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Share to Amino Acid Substitution
Share to Antibiotics, Antitubercular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Drug Resistance, Multiple, Bacterial

Share to Mutation, Missense

Share to Mycobacterium tuberculosis

Share to Rifampin

Share to Tuberculosis, Multidrug-Resistant

Source

Identifiers

PMID: 16809538
DOI: 10.1126/science.1124410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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