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Article

The competitive cost of antibiotic resistance in Mycobacterium tuberculosis.

Science (New York, N.Y.) - 30 Jun 2006

Gagneux Sebastien, Long Clara Davis, Small Peter M, Van Tran, Schoolnik Gary K, Bohannan Brendan J M

Abstract excerpt

Mathematical models predict that the future of the multidrug-resistant tuberculosis epidemic will depend on the fitness cost of drug resistance. We show that in laboratory-derived mutants of Mycobacterium tuberculosis, rifampin resistance is universally associated with a competitive fitness cost...

Read the complete abstract on PubMed

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Share to Amino Acid Substitution
Share to Antibiotics, Antitubercular
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Mutation, Missense

Share to Mycobacterium tuberculosis

Share to Rifampin

Share to Tuberculosis, Multidrug-Resistant

Source

Identifiers

PMID: 16809538
DOI: 10.1126/science.1124410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16809538-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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