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Article

The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011

Kappes Gretchen, Deshpande Girish, Mulvey Brett B, Horabin Jamila I, Schedl Paul

Abstract excerpt

The binary switch gene Sex-lethal (Sxl) controls sexual identity in Drosophila. When activated, Sxl imposes female identity, whereas male identity ensues by default when the gene is off. The decision to activate Sxl is controlled by an X chromosome counting system that regulates the Sxl establishment promoter, Sxl-Pe. The counting system depends upon the twofold difference in the gene dose of a series of X-linked...

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Identifiers

PMID: 21220321
DOI: 10.1073/pnas.1017006108
PMCID: PMC3029748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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