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Mechanisms of sex determination and X-chromosome dosage compensation

6 Jan 2022

Abstract excerpt

Abnormalities in chromosome number have the potential to disrupt the balance of gene expression and thereby decrease organismal fitness and viability. Such abnormalities occur in most solid tumors and also cause severe developmental defects and spontaneous abortions. In contrast to the imbalances in chromosome dose that cause pathologies, the difference in X-chromosome dose used to determine sexual fate across...

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PMID: 35100381
DOI: 10.1093/genetics/iyab197

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