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Article

The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex.

Nature - 12 Nov 1998

Carmi I, Kopczynski J B, Meyer B J

Abstract excerpt

Organisms in many phyla determine sexual fate by distinguishing one X chromosome from two. Here we use the model organism Caenorhabditis elegans to dissect such an X-chromosome-counting mechanism in molecular detail. In this nematode, several genes on the X chromosome called X signal elements communicate X-chromosome dose by controlling the activity of the sex-determination gene xol-1. xol-1 specifies male (XO)...

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PMID: 9823896
DOI: 10.1038/24164

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