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Article

The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.

Developmental cell - 1 Sept 2005

Powell Jennifer R, Jow Margaret M, Meyer Barbara J

Abstract excerpt

Sex is determined in C. elegans by a chromosome-counting mechanism that tallies X chromosome dose relative to the sets of autosomes, the X:A ratio. A group of genes on X called X signal elements (XSEs) communicates X chromosome number by repressing the activity of the master sex-determination switch gene xol-1 in a dose-dependent manner. xol-1 is repressed by transcriptional and posttranscriptional mechanisms and...

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Identifiers

PMID: 16139225
DOI: 10.1016/j.devcel.2005.06.009
PMCID: PMC2649673

Genes

SEA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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