Article
Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster.
Genetics - 1 Dec 1995
Barbash D A, Cline T W
Abstract excerpt
Drosophila sex is determined by the action of the X:A chromosome balance on transcription of Sex-lethal (Sxl), a feminizing switch gene. We obtained loss-of-function mutations in denominator elements of the X:A signal by selecting for dominant suppressors of a female-specific lethal mutation in the numerator element, sisterlessA (sisA). Ten suppressors were recovered in this extensive genome-wide selection. All...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Transcription Factors
- DNA Primers
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Genes, Suppressor
- Genetic Complementation Test
- Male