Article
An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2011
Kucera Nathan J, Hodsdon Michael E, Wolin Sandra L
Abstract excerpt
The La protein binds the 3' ends of many newly synthesized noncoding RNAs, protecting these RNAs from nucleases and influencing folding, maturation, and ribonucleoprotein assembly. Although 3' end binding by La involves the N-terminal La domain and adjacent RNA recognition motif (RRM), the mechanisms by which La stabilizes diverse RNAs from nucleases and assists subsequent events in their biogenesis are unknown....
Topics
- Amino Acid Sequence
- Anticodon
- Chymotrypsin
- Electrophoretic Mobility Shift Assay
- Immunoblotting
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Binding
- Protein Structure, Tertiary
- RNA Precursors
- RNA, Fungal