Article
A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts.
The EMBO journal - 15 Dec 1998
Pannone B K, Xue D, Wolin S L
Abstract excerpt
The first protein that binds to all newly synthesized RNA polymerase III transcripts is a highly conserved phosphoprotein known as the La autoantigen. Although binding by the yeast La protein Lhp1p to pre-tRNAs is required for the normal pathway of tRNA maturation, the role of the La protein in the biogenesis of other polymerase III transcripts has been unclear. We identified a mutation in a novel component of...
Topics
- Amino Acid Sequence
- Autoantigens
- Fungal Proteins
- Gene Dosage
- Molecular Chaperones
- Molecular Sequence Data
- Mutation
- N-Terminal Acetyltransferase C
- RNA Polymerase III
- RNA Precursors
- RNA, Fungal
- RNA, Messenger
- RNA-Binding Proteins