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Article

The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors.

Cell - 2 May 1997

Yoo C J, Wolin S L

Abstract excerpt

Although the La autoantigen binds to the 3' ends of all nascent polymerase III transcripts, its function in vivo has long been unclear. Although S. cerevisiae cells lacking the La protein homolog Lhp1p are viable, cells containing a mutation that disrupts the anticodon stem of tRNA(Ser)CGA require Lhp1p for growth. We demonstrate that for the wild-type pre-tRNA(Ser)CGA and other pre-tRNAs, Lhp1p is required for...

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Source

Identifiers

PMID: 9150139
DOI: 10.1016/s0092-8674(00)80220-2

Genes

CGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The yeast La protein is required for the 3' endonucleolytic cleavage that matures tRNA precursors.PMID 9150139Read ↗

An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.Semantic proximity Read ↗

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Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.Semantic proximity Read ↗

The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression.Semantic proximity Read ↗

Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing.Semantic proximity Read ↗

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