Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.

Nucleic acids research - 25 Jan 2017

Wasmuth Elizabeth V, Lima Christopher D

Abstract excerpt

The eukaryotic RNA exosome is an essential, multi-subunit complex that catalyzes RNA turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core includes 9 subunits that associate with the 3' to 5' exoribonucleases Rrp6, and Rrp44/Dis3, a subunit that also catalyzes endoribonuclease activity. Although recent structures and biochemical studies of RNA bound exosomes from S. cerevisiae...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exoribonucleases
Share to Exosome Multienzyme Ribonuclease Complex
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Conformation

Share to Protein Binding

Share to Protein Interaction Domains and Motifs

Share to RNA Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 27899565
DOI: 10.1093/nar/gkw1152
PMCID: PMC5314766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.PMID 27899565Read ↗

Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.Semantic proximity Read ↗

The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.Semantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain.Semantic proximity Read ↗

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.Semantic proximity Read ↗

The RNA exosome complex central channel controls both exonuclease and endonuclease Dis3 activities in vivo and in vitro.Semantic proximity Read ↗

SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responsesSemantic proximity Read ↗

The CR3 motif of Rrp44p is important for interaction with the core exosome and exosome function.Semantic proximity Read ↗

A nuclear RNA degradation code for eukaryotic transcriptome surveillanceSemantic proximity Read ↗

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs.Semantic proximity Read ↗

Extensive degradation of RNA precursors by the exosome in wild-type cells.Semantic proximity Read ↗

RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.