Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets.

Nucleic acids research - 2 Nov 2017

Vakiloroayaei Ana, Shah Neha S, Oeffinger Marlene, Bayfield Mark A

Abstract excerpt

Non-coding RNAs have critical roles in biological processes, and RNA chaperones can promote their folding into the native shape required for their function. La proteins are a class of highly abundant RNA chaperones that contact pre-tRNAs and other RNA polymerase III transcripts via their common UUU-3'OH ends, as well as through less specific contacts associated with RNA chaperone activity. However, whether La...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Models, Molecular
Share to RNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to RNA Folding

Share to RNA Precursors

Share to RNA Processing, Post-Transcriptional

Share to RNA, Transfer

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28977649
DOI: 10.1093/nar/gkx764
PMCID: PMC5737608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets.PMID 28977649Read ↗

Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast speciesSemantic proximity Read ↗

Molecular chaperones and quality control in noncoding RNA biogenesis.Semantic proximity Read ↗

Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.Semantic proximity Read ↗

Methylated nucleosides in tRNA and tRNA methyltransferasesSemantic proximity Read ↗

An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors.Semantic proximity Read ↗

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read ↗

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read ↗

Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.Semantic proximity Read ↗

Disease associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation and tRNA processing by mtRNase PSemantic proximity Read ↗

Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P.Semantic proximity Read ↗

tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast.Semantic proximity Read ↗

tRNA modifications and tRNA-derived small RNAs: new insights of tRNA in human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.