The RNA chaperone La promotes pre-tRNA maturation via indiscriminate binding of both native and misfolded targets.

Abstract excerpt

Non-coding RNAs have critical roles in biological processes, and RNA chaperones can promote their folding into the native shape required for their function. La proteins are a class of highly abundant RNA chaperones that contact pre-tRNAs and other RNA polymerase III transcripts via their common UUU-3'OH ends, as well as through less specific contacts associated with RNA chaperone activity. However, whether La...

Topics

• Models, Genetic
• Models, Molecular
• Mutation
• Protein Binding
• RNA Folding
• RNA Precursors
• RNA Processing, Post-Transcriptional
• RNA, Transfer
• RNA-Binding Proteins
• Schizosaccharomyces
• Schizosaccharomyces pombe Proteins