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Article

Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.

The EMBO journal - 10 Mar 2004

Dong Gang, Chakshusmathi Ghadiyaram, Wolin Sandra L, Reinisch Karin M

Abstract excerpt

The La protein is a ubiquitous nuclear phosphoprotein that recognizes the 3' uridylates found in all newly synthesized RNA polymerase III transcripts. La binding stabilizes these transcripts from exonucleases and may also assist their folding. Here we present the first structural insights into how the La protein specifically interacts with its RNA substrates. The most conserved region of the La protein is the La...

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Identifiers

PMID: 14976553
DOI: 10.1038/sj.emboj.7600115
PMCID: PMC380972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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