Article
Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.
The EMBO journal - 10 Mar 2004
Dong Gang, Chakshusmathi Ghadiyaram, Wolin Sandra L, Reinisch Karin M
Abstract excerpt
The La protein is a ubiquitous nuclear phosphoprotein that recognizes the 3' uridylates found in all newly synthesized RNA polymerase III transcripts. La binding stabilizes these transcripts from exonucleases and may also assist their folding. Here we present the first structural insights into how the La protein specifically interacts with its RNA substrates. The most conserved region of the La protein is the La...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Autoantigens
- Conserved Sequence
- Crystallography, X-Ray
- Helix-Turn-Helix Motifs
- Hydroxylation
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Phosphates
- Protein Binding
- Protein Structure, Tertiary