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Article

MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context.

Haematologica - 1 May 2011

Kleppe Maria, Mentens Nicole, Tousseyn Thomas, Wlodarska Iwona, Cools Jan

Abstract excerpt

The mouse pro-B cell line Ba/F3 has gained major interest as a model system to investigate oncogenic tyrosine kinases and to determine the efficacy of kinase inhibitors. While Ba/F3 cells are suitable to study oncogenic kinases derived from various cell types, the signaling networks in Ba/F3 cells are B-cell specific. We have established a mouse CD4+CD8+ double positive T-cell line (named MOHITO, for MOuse...

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Source

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Identifiers

PMID: 21193420
DOI: 10.3324/haematol.2010.035931
PMCID: PMC3084928

Genes

ABL1
BCR
JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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