Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.

doi:10.4049/jimmunol.180.8.5466

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Article

Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2008

Mayerhofer Matthias, Gleixner Karoline V, Hoelbl Andrea, Florian Stefan, Hoermann Gregor, Aichberger Karl J, Bilban Martin, Esterbauer Harald, Krauth Maria-Theresa, Sperr Wolfgang R, Longley Jack B, Kralovics Robert, Moriggl Richard, Zappulla Jacques, Liblau Roland S, Schwarzinger Ilse, Sexl Veronika, Sillaber Christian, Valent Peter

Abstract excerpt

Oncogenic tyrosine kinases (TK) usually convert growth factor-dependent cells to factor independence with autonomous proliferation. However, TK-driven neoplasms often are indolent and characterized by cell differentiation rather than proliferation. A prototype of an indolent TK-driven neoplasm is indolent systemic mastocytosis. We found that the D816V-mutated variant of KIT, a TK detectable in most patients with...

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PMID: 18390729
DOI: 10.4049/jimmunol.180.8.5466
PMCID: PMC2976849

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Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens.PMID 18390729Read ↗

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