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Article

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Blood - 13 Nov 2014

Degryse Sandrine, de Bock Charles E, Cox Luk, Demeyer Sofie, Gielen Olga, Mentens Nicole, Jacobs Kris, Geerdens Ellen, Gianfelici Valentina, Hulselmans Gert, Fiers Mark, Aerts Stein, Meijerink Jules P, Tousseyn Thomas, Cools Jan

Abstract excerpt

JAK3 is a tyrosine kinase that associates with the common γ chain of cytokine receptors and is recurrently mutated in T-cell acute lymphoblastic leukemia (T-ALL). We tested the transforming properties of JAK3 pseudokinase and kinase domain mutants using in vitro and in vivo assays. Most, but not all, JAK3 mutants transformed cytokine-dependent Ba/F3 or MOHITO cell lines to cytokine-independent proliferation. JAK3...

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Identifiers

PMID: 25193870
DOI: 10.1182/blood-2014-04-566687

Genes

JAK3
JAK1
F3
IL7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.PMID 25193870Read ↗

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