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Article

BTK: a two-faced effector in cancer and tumour suppression

18 Oct 2018

Abstract excerpt

Many genes of the human genome display pleiotropic activity, playing an important role in two or more unrelated pathways. Surprisingly, some of these functions can even be antagonistic, often letting to divergent functional outcomes depending on microenviromental cues and tissue/cell type-dependent parameters. Lately, the Bruton's tyrosine kinase (BTK) has emerged as one of such pleiotropic genes, with opposing...

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PMID: 30337526
DOI: 10.1038/s41419-018-1122-8

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