Article
A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia.
Blood - 13 Jun 2024
Klein Klara, Kollmann Sebastian, Hiesinger Angela, List Julia, Kendler Jonatan, Klampfl Thorsten, Rhandawa Mehak, Trifinopoulos Jana, Maurer Barbara, Grausenburger Reinhard, Betram Christof A, Moriggl Richard, Rülicke Thomas, Mullighan Charles G, Witalisz-Siepracka Agnieszka, Walter Wencke, Hoermann Gregor, Sexl Veronika, Gotthardt Dagmar
Abstract excerpt
ABSTRACT: Patients with T- and natural killer (NK)-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5BN642H, which is known to drive murine T-cell leukemia, although its role in NK-cell malignancies is unclear. Introduction of the STAT5BN642H mutation into human NK-cell lines enhances their potential to induce leukemia in mice. We have generated a...
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