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Lessons in Signaling and Tumorigenesis from Polyomavirus Middle T Antigen

31 Aug 2009

Abstract excerpt

The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on cancer-related signaling. Here we review murine polyomavirus middle T antigen, its mechanisms, and its downstream pathways of transformation. We concentrate on the MMTV-PyMT transgenic mouse, one of the most studied models of breast...

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PMID: 19721090
DOI: 10.1128/mmbr.00009-09

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