Article

A lineage-specific <i>STAT5B</i> <sup>N642H</sup> mouse model to study NK-cell leukemia

2023-10-06

Abstract excerpt

Patients with T- and NK-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5B N642H , which is known to drive murine T-cell leukemia although its role in NK-cell malignancies is unclear. Introduction of the STAT5B N642H mutation into human NK-cell lines enhances their potential to induce leukemia in mice. We have generated a mouse model that enab...

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Literature Corpus work: 5951d460-7bb8-56c1-9f08-a57ec9414afd
DOI: 10.1101/2023.10.04.560502

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