Utilization of Pathway Signatures to Reveal Distinct Types of B Lymphoma in the Eμ- myc Model and Human Diffuse Large B-Cell Lymphoma

Abstract excerpt

The Emu-myc transgenic mouse has provided a valuable model for the study of B-cell lymphoma. Making use of gene expression analysis and, in particular, expression signatures of cell signaling pathway activation, we now show that several forms of B lymphoma can be identified in the Emu-myc mice associated with time of tumor onset. Furthermore, one form of Emu-myc tumor with pre-B character is shown to resemble...

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