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Article

Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2009

Müller Martin R, Sasaki Yoshiteru, Stevanovic Irena, Lamperti Edward D, Ghosh Srimoyee, Sharma Sonia, Gelinas Curtis, Rossi Derrick J, Pipkin Matthew E, Rajewsky Klaus, Hogan Patrick G, Rao Anjana

Abstract excerpt

NFAT transcription factors are highly phosphorylated proteins residing in the cytoplasm of resting cells. Upon dephosphorylation by the phosphatase calcineurin, NFAT proteins translocate to the nucleus, where they orchestrate developmental and activation programs in diverse cell types. NFAT is rephosphorylated and inactivated through the concerted action of at least 3 different kinases: CK1, GSK-3, and DYRK. The...

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Identifiers

PMID: 19351896
DOI: 10.1073/pnas.0813296106
PMCID: PMC2678457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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