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Article

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast.

Cell cycle (Georgetown, Tex.) - 1 Jan 2011

Delaney Joe R, Murakami Christopher J, Olsen Brady, Kennedy Brian K, Kaeberlein Matt

Abstract excerpt

Reduced fecundity has been associated with some alleles that enhance longevity in invertebrate and mammalian models. This observation has been suggested to support the antagonistic pleiotropy theory of aging, which predicts that alleles of some genes promoting fitness early in life have detrimental effects later in life that limit survival. In only a few cases, however, has the relative fitness of long-lived...

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Identifiers

PMID: 21191185
DOI: 10.4161/cc.10.1.14457
PMCID: PMC3048082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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