Article
Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies.
Proceedings of the National Academy of Sciences of the United States of America - 18 Mar 2003
Marden James H, Rogina Blanka, Montooth Kristi L, Helfand Stephen L
Abstract excerpt
Alterations that extend the life span of animals and yeast typically involve decreases in metabolic rate, growth, physical activity, and/or early-life fecundity. This negative correlation between life span and the ability to assimilate and process energy, to move, grow, and reproduce, raises questions about the potential utility of life span extension. Tradeoffs between early-life fitness and longevity are...
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