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Article

Antagonistically pleiotropic allele increases lifespan and late-life reproduction at the cost of early-life reproduction and individual fitness.

Proceedings. Biological sciences - 14 Jun 2017

Maklakov Alexei A, Carlsson Hanne, Denbaum Philip, Lind Martin I, Mautz Brian, Hinas Andrea, Immler Simone

Abstract excerpt

Evolutionary theory of ageing maintains that increased allocation to early-life reproduction results in reduced somatic maintenance, which is predicted to compromise longevity and late-life reproduction. This prediction has been challenged by the discovery of long-lived mutants with no loss of fecundity. The first such long-lived mutant was found in the nematode worm Caenorhabditis elegans Specifically, partial...

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Identifiers

PMID: 28615498
DOI: 10.1098/rspb.2017.0376
PMCID: PMC5474071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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