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Article

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study.

Aging - 1 Jan 2011

Mooijaart Simon P, van Heemst Diana, Noordam Raymond, Rozing Maarten P, Wijsman Carolien A, de Craen Anton J M, Westendorp Rudi G J, Beekman Marian, Slagboom P Eline

Abstract excerpt

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results from loss of glucose homeostasis and for which new candidate polymorphisms now rapidly emerge from genome wide association studies. In the Leiden Longevity Study (n=2415), the offspring of long lived siblings...

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Identifiers

PMID: 21191145
DOI: 10.18632/aging.100250
PMCID: PMC3047139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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