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Genetic susceptibility, obesity and lifetime risk of type 2 diabetes: The ARIC study and Rotterdam Study.

Diabetic medicine : a journal of the British Diabetic Association - 1 Oct 2021

Ligthart Symen, Hasbani Natalie R, Ahmadizar Fariba, van Herpt Thijs T W, Leening Maarten J G, Uitterlinden André G, Sijbrands Eric J G, Morrison Alanna C, Boerwinkle Eric, Pankow James S, Selvin Elizabeth, Ikram M Arfan, Kavousi Maryam, de Vries Paul S, Dehghan Abbas

Abstract excerpt

AIMS: Both lifestyle factors and genetic background contribute to the development of type 2 diabetes. Estimation of the lifetime risk of diabetes based on genetic information has not been presented, and the extent to which a normal body weight can offset a high lifetime genetic risk is unknown. METHODS: We used data from 15,671 diabetes-free participants of European ancestry aged 45 years and older from the...

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Identifiers

PMID: 34245042
DOI: 10.1111/dme.14639
PMCID: PMC8429251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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