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<i>In Vitro</i> Activities of Arylomycin Natural-Product Antibiotics against <i>Staphylococcus epidermidis</i> and Other Coagulase-Negative Staphylococci

29 Dec 2010

Abstract excerpt

The arylomycins are a class of natural-product antibiotics that act via the inhibition of type I signal peptidase (SPase), and we have found in diverse bacteria that their activity is limited by the presence of a resistance-conferring Pro residue in SPase that reduces inhibitor binding. We have also demonstrated that Staphylococcus epidermidis, which lacks this Pro residue, is extremely susceptible to the...

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PMID: 21189343
DOI: 10.1128/aac.01459-10

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