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<i>In Vitro</i> and <i>In Vivo</i> Investigations into the Potential of Quinazoline and Quinoline Derivatives as NorA Efflux Pump Inhibitors Against Resistant <i>Staphylococcus aureus</i> Strains

2025-02-18

Abstract excerpt

<h4>Background: </h4> Staphylococcus aureus is a highly lethal Gram-positive bacterium that is responsible for over one million deaths annually. As a member of the ESKAPE pathogens, its methicillin-resistant strains (MRSA) are prevalent worldwide and exhibit significant antimicrobial resistance (AMR). Bacterial efflux pumps play a pivotal role in the development of AMR by facilitating the expulsion of a range of a...

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Literature Corpus work
24b67ab3-7d82-529d-9c12-7e02bbf87332
DOI
10.20944/preprints202502.1344.v1
Open publication

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<i>In Vitro</i> and <i>In Vivo</i> Investigations into the Potential of Quinazoline and Quinoline Derivatives as NorA Efflux Pump Inhibitors Against Resistant <i>Staphylococcus aureus</i> StrainsDOI 10.20944/preprints202502.1344.v1
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