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Structure–Function Analyses of a <i>Staphylococcus epidermidis</i> Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation

9 May 2016

Abstract excerpt

Staphylococcus epidermidis is frequently implicated in human infections associated with indwelling medical devices due to its ubiquity in the skin flora and formation of robust biofilms. The accessory gene regulator (agr) quorum sensing (QS) system plays a prominent role in the establishment of biofilms and infection by this bacterium. Agr activation is mediated by the binding of a peptide signal (or autoinducing...

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PMID: 27159024
DOI: 10.1021/acschembio.6b00120

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