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Article

<i>In vitro</i> and <i>in vivo</i> activity profiles of broad-spectrum bacterial ATP synthase inhibitors

2025-08-23

Abstract excerpt

Tomatidine ( TO ), a natural steroidal alkaloid derived from Solanaceae (e.g., tomato), is recognized for its narrow-spectrum antibiotic activity, particularly against persistent forms of Staphylococcus aureus , such as small-colony variants (SCVs). Previous studies have shown that TO exerts its effect by inhibiting S. aureus ATP synthase. In earlier work, we synthesized nearly 100 TO analogs featuring an eth...

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Identifiers and source

Literature Corpus work
6185aae9-96dc-5b21-9fe0-58f5ab3d5000
DOI
10.1101/2025.08.21.671483
Open publication

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